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Isaac is now a Category One hurricane with 75 mile per hour winds as it approaches the Gulf Coast.

The National Hurricane Center expects the storm to make landfall Tuesday evening near the mouth of the Mississippi River.

President Obama declared a state of emergency for Louisiana, and urged residents in the storm’s path to use extreme caution.

"I want to encourage all residents of the Gulf Coast to listen to your local officials and follow their directions,” the president said. “Including if they tell you to evacuate."

The president said that for the past week FEMA has been present in areas that could be affected by Isaac. The federal response officials are working with local leaders on plans to keep residents safe.

New Orleans Mayor Mitch Landrieu says the city is ready for the storm.

"You can see just as the ramp up to this storm, the relationship between the federal, state and local governments. Just yesterday, we were on a call with President Obama,” Landrieu said. “We have the governors of Alabama, Mississippi and Louisiana. We had the mayor of New Orleans, parish presidents. We're all talking, we're all lined up, we're all ready to go. However, I will say this--all of this is still driven by citizens doing the right thing, at the right time, in the right place, with common sense."

No evacuation orders have been issued for New Orleans. Residents in South Florida are dealing with massive flooding after Isaac passed through the area.

The brunt of the storm spared the Florida peninsula, including Tampa where the Republican National Convention is underway.