Updated 02/10/2012 08:54 AM
Your Health: Pros and cons of Provenge
By: Ivanhoe Broadcast News
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Aside from non-melanoma skin cancer, prostate cancer is the most common form of cancer among men in the United States. According to the Center for Disease Control, there were 240,000 estimated new cases and deaths from prostate cancer in 2011.
Tora Vinci
Media Relations
Cleveland Clinic
(216)444 -2412
vinciv@ccf.org
Provenge is a cell therapy that aims to train the immune system to attack tumor cells. It's made using cells from a patient's own immune system, so it cannot be warehoused like many other drugs.
The process of making Provenge involves the exposure of a patient's immune cells to a protein that functions as a prostate cancer-associated antigen.
An antigen is a substance that causes the body to react with an immune response. This process activates the patient's immune cells against prostate cancer to help the immune system better fight the disease. The most common side effects reported with Provenge are chills, fatigue, fever, back pain, nausea, joint ache and headache. These are not all the possible side effects of Provenge treatment.
A new survey of cancer doctors found the miracle drug has some cons as well. The percentage of patients deemed eligible for Provenge seems to be going down, declining from 37 percent to 24 percent.
Of the 67 percent of total responders who did not have access to Provenge at the time of the survey, just 50 percent indicate they will prescribe Provenge once it becomes available.
A new study published in the New England Journal of Medicine shows, the newly-approved prostate cancer pill Zytiga may extend life by up to four months in men with spreading cancer who’ve already been treated with chemotherapy. It inhibits a protein that helps form male hormones.
Men who took the new pill also saw greater responses in levels of prostate-specific antigen (PSA) than men who received placebo. This survival edge was considered so significant that men who received the placebo were permitted to switch to the new drug before the study was completed.